April 17, 2011

CYP2A6 allele frequencies in Ecuador

Dear friends:
Recently, our research team published a new paper on Population Genetics related with Pharmacology and Forensics applications. Here you have the abstract

by Soriano A, Vicente J, Carcas C, Gonzalez-Andrade Fabricio, Arenaz I, Martinez-Jarreta B, Fanlo A, Mayayo E, Sinués B and, published in Fundam Clin Pharmacol. 2011 Mar 17. doi: 10.1111/j.1472-8206.2010.00889.x.

This study was designed to investigate the potential differences between Spaniards and Ecuadorian Mestizo people regarding CYP2A6*1A, CYP2A6*1B1, CYP2A6*1x2A, CYP2A6*9A, and CYP2A6*4A variant alleles at the CYP2A6 gene and also to compare the observed frequencies with those previously reported in different ethnic groups. DNA from 234 Spaniard and 300 Ecuadorian subjects were analyzed by either PCR or PCR-restriction fragment length polymorphism. Differences between Spaniards and Mestizo Ecuadorians were detected in relation to the frequencies of the alleles linked to either absent enzyme activity, CYP2A6*4A (4 and 7.1%, respectively), or reduced CYP2A6 enzyme activity, CYP2A6*9A (6.4 and 10.3%, respectively). CYP2A6*4A and CYP2A6*9A frequencies in Ecuadorians were higher than those in Africans or Caucasian groups and lower than those in Asians. This study provides, for the first time, the result of the analysis of CYP2A6 allele frequency in a South American population and demonstrates the presence of ethnic differences in CYP2A6 genetic variants between Spaniards and Mestizo Ecuadorians, which should be considered in allele-disease association studies and, in particular, in those involving CYP2A6 genetic polymorphisms and tobacco-related cancer.

Keywords: CYP2A6 polymorphism; Ecuadorians; ethnic differences; pharmacogenetic markers; Spaniards

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