September 28, 2011

Fuentes de información médica en Internet

Mis estimados lectores:

Un gran amigo mío ha hecho una compilación de direcciones útiles para búsqueda de información en medicina, casi todas con acceso gratuito, algunas de ellas requieren registro gratis, solo dos de ellas requieren suscripción pagada. Me parece muy útil compartirla con vosotros.

Vademécums

Diagnóstico diferencial

Metabuscadores
Health Systems Evidence (políticas en salud)

Sumarios
Libros electrónicos basados en evidencia
BMJ Best Practice (requiere suscripción pagada)
DynaMed (requiere suscripción pagada)

Guías de práctica clínica

Sinopsis de la evidencia publicada

Síntesis

eStudios

Typing ecuadorians with the SNPforID multiplex.

This is our last paper published. Enjoy it!


Abstract
A total of 119 unrelated individuals from two of the major ethnic groups in Ecuador were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex using the SNapShot(®) assay. Of the above, 42 samples originated from Mestizos (an admixed population) and the remaining 77 were from Native Amerindian Kichwas. We obtained full SNP profiles in all individuals and concordance of duplicated analyses. No deviation from Hardy-Weinberg equilibrium (HWE) was observed for any SNP in the Mestizo and Kichwa populations and only one and four pairs of loci, respectively showed significant linkage disequilibrium. A relatively low genetic diversity and global positive F(IS) value was observed in Kichwas. A statistically significant global F(ST) value was obtained when the two Ecuadorian populations were compared with populations in Spain, Portugal, Argentina, Denmark, Greenland, China, Somalia and Mozambique. All pairwise F(ST) values were statistically significant. A multi-dimensional scaling based on pairwise F(ST) values showed that the Kichwa population differed from all other populations investigated and that the Mestizos had an intermediate position between Kichwas and Europeans. An admixture analysis indicated that the greater contributor to the Mestizo population was the Kichwas (71.2%) compared to the European contribution. The combined mean match probability and mean paternity exclusion probability were 3.3 × 10(-17) and 0.998, respectively, for the Mestizo population and 3.3 × 10(-14) and 0.993, respectively, for the Kichwa population.